The vascular system, composed of endothelial cells, extends all around the body’s periphery and into and around all structures of the brain. As we age, our arteries physically stiffen and the endothelial cells (the innermost cell layer of our blood vessels) become less responsive to molecular cues in the blood, leading to an overall decrease in blood flow and increase in cardiovascular dysfunction, which often manifests as cardiovascular disease (Bolduc et al., 2013). These